RANKL/RANK control Brca1 mutation-driven mammary tumors
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چکیده
منابع مشابه
Hspb1 and Tp53 Mutation and Expression Analysis in Cat Mammary Tumors
Background: Molecular marker based cancer diagnosis gaining more attention in the current genomics era. So, Hspb1 and Tp53 gene characterization and their mRNA expression might be helpful in diagnosis andprognosis ofcat mammary adenocarcinoma. It will also add informationin comparative cancer genetics and genomics. Objectives: Eight tumors of Siamese cats were analyzed to ascertain germ-line an...
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Cancer is the one of the main causes of death in cats and dogs, while it is the second most cause of deaths in humans. In third world countries, less attention is paid to the health of pets. The genes (COX-2 and BRCA1) are selected to study the mutation and gene expressional profiling (qPCR, Real Time PCR) in mammary tumor of cats. Being mammals, cats are studied as a model as they may suffer f...
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PTEN loss and PIK3CA activation both promote the accumulation of phosphatidylinositol (3, 4, 5)-trisphosphate (PIP3). While these proteins also have distinct biochemical functions, beyond the regulation of PIP3, little is known about the consequences of these differences in vivo. Here, we directly compared cancer signalling in mammary tumors from MMTV-Cre:Ptenf/f and MMTV-Cre:Pik3ca(LSL-H1047R)...
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Bcl3 is a putative proto-oncogene deregulated in hematopoietic and solid tumors. Studies in cell lines suggest that its oncogenic effects are mediated through the induction of proliferation and inhibition of cell death, yet its role in endogenous solid tumors has not been established. Here, we address the oncogenic effect of Bcl3 in vivo and describe how this Stat3-responsive oncogene promotes ...
متن کاملClassification and grading of canine malignant mammary tumors
Histological grading is a good parameter to stratify tumors according to their biological aggressiveness. The Elston and Ellis grading method in humans, invasive ductal breast carcinomas and other invasive tumors are routinely used. The aims of this study were classification of mammary gland tumors and also application of a human grading method in canine mammary carcinoma. The samples included ...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2016
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2016.69